論文 Research papers

#equal contributions

  1. Ryuichi Hishida, Takayoshi Otsuka, Shinya Toyokuni, and Hideaki Matsui (2026). Structural and metabolic signatures of cardiac aging in African turquoise killifish (Nothobranchius furzeri). Histol Histopathol. ahead of print https://doi.org/10.14670/HH-25-143
  2. Takayoshi Otsuka and Hideaki Matsui (2026). Loss of tissue-state plasticity: a conceptual framework for age-associated regenerative failure. Inflamm Regener. https://doi.org/10.1186/s41232-026-00435-3
  3. Godfried Dougnon, Takayoshi Otsuka, Yuka Nakamura, Akiko Sakai, Tomoyuki Yamanaka, Noriko Matsui, Asa Nakahara, Ai Ito, Atsushi Hatano, Masaki Matsumoto, Hironaka Igarashi, Akiyoshi Kakita, Masaki Ueno, and Hideaki Matsui (2026). A protective role for APP in nuclear waste clearance via lysosomal exocytosis, Proc. Natl. Acad. Sci. U.S.A. 123 (24) e2524190123, https://doi.org/10.1073/pnas.2524190123.
  4. Ummay Ayman, Takayoshi Otsuka, Godfried Dougnon, and Hideaki Matsui (2026). Crosstalk between ApoE-expressing cells and genotoxic stress in the mouse brain. Brain Res. 1871: 150080. https://doi.org/10.1016/j.brainres.2025.150080
  5. Takayoshi Otsuka, Atsushi Hatano, Masaki Matsumoto, and Hideaki Matsui (2025). A Robust Protocol for Proteomic Profiling of Secreted Proteins in Conditioned Culture Medium. Biol Methods and Protoc. 10 (1), bpaf068. https://doi.org/10.1093/biomethods/bpaf068
  6. Takayoshi Otsuka and Hideaki Matsui (2025). The African turquoise killifish (Nothobranchius furzeri): A model of age-related diseases and declining regenerative capability across multiple organs. Mech Ageing Dev. 226, 112087. https://doi.org/10.1016/j.mad.2025.112087
  7. Mohammed A. Barajaa, Takayoshi Otsuka, and Cato T. Laurencin (2025). A novel protocol for the direct isolation of a highly pure and regenerative population of satellite stem cells. Proc Natl Acad Sci U S A. 122 (25) e2426081122. https://doi.org/10.1073/pnas.2426081122
  8. Maumita Bhattacharjee #, Takayoshi Otsuka #, Godwin K. Dzidotor, Lakshmi S. Nair, and Cato T. Laurencin (2024). Amnion-Based Biomaterials for Musculoskeletal Regenerative Engineering. Regen. Eng. Transl. Med. 10, 441–460. https://doi.org/10.1007/s40883-023-00321-1
  9. Shiv Shah, Debolina Ghosh, Takayoshi Otsuka, and Cato T. Laurencin (2024). Classes of Stem Cells: From Biology to Engineering. Regen. Eng. Transl. Med. 10, 309–322. https://doi.org/10.1007/s40883-023-00317-x
  10. Mohammed A. Barajaa, Takayoshi Otsuka, Debolina Ghosh, Ho-Man Kan, and Cato T. Laurencin (2024). Development of porcine skeletal muscle extracellular matrix–derived hydrogels with improved properties and low immunogenicity. Proc Natl Acad Sci U S A. 121(19), e2322822121. https://doi.org/10.1073/pnas.2322822121
  11. Godfried Dougnon, Takayoshi Otsuka, Yuka Nakamura, Akiko Sakai, Tomoyuki Yamanaka, Noriko Matsui, Asa Nakahara, Ai Ito, Atsushi Hatano, Masaki Matsumoto, Hironaka Igarashi, Akiyoshi Kakita, Masaki Ueno and Hideaki Matsui (2024). Extracellular disposal of nuclear waste by APP: a protective mechanism impaired in Alzheimer's disease. bioRxiv. https://doi.org/10.1101/2024.02.10.579739
  12. Takayoshi Otsuka, Ho-Man Kan, Paulos Y. Mengsteab, Breajah Tyson, and Cato T. Laurencin (2024). Fibroblast growth factor 8b (FGF-8b) enhances myogenesis and inhibits adipogenesis in rotator cuff muscle cell populations in vitro. Proc Natl Acad Sci U S A. 121(1), e2314585121. https://doi.org/10.1073/pnas.2314585121
  13. Nikoo Saveh Shemshaki, Mohammed A. Barajaa, Takayoshi Otsuka, Elnaz S. Mirdamadi, Lakshmi S. Nair, and Cato T. Laurencin (2023). Electroconductivity, a Regenerative Engineering Approach to Reverse Rotator Cuff Muscle Degeneration. Regen Biomater. 10, rbad099, https://doi.org/10.1093/rb/rbad099
  14. Nikoo Saveh Shemshaki, Ho-Man Kan, Mohammed A. Barajaa, Amir Lebaschi, Takayoshi Otsuka, Neha Mishra, Lakshmi S. Nair, and Cato T. Laurencin (2023). Efficacy of a Novel Electroconductive Matrix To Treat Muscle Atrophy and Fat Accumulation in Chronic Massive Rotator Cuff Tears of the Shoulder. ACS Biomater Sci Eng. 9(10), 5782-5792. https://doi.org/10.1021/acsbiomaterials.3c00585
  15. Takayoshi Otsuka and Hideaki Matsui (2023). Fish Models for Exploring Mitochondrial Dysfunction Affecting Neurodegenerative Disorders. Int J Mol Sci. 24(8), 7079. https://doi.org/10.3390/ijms24087079
  16. Takayoshi Otsuka, Ho-Man Kan, Timothy D. Mason, Lakshmi S. Nair, and Cato T. Laurencin (2022). Overexpression of NDST1 Attenuates Fibrotic Response in Murine Adipose-Derived Stem Cells. Stem Cells Dev. 31(23–24), 787–798. https://doi.org/10.1089/scd.2022.0053
  17. Nikoo Saveh Shemshaki, Ho-Man Kan, Mohammed A. Barajaa, Takayoshi Otsuka, Amir Lebaschi, Neha Mishra, Lakshmi S. Nair, and Cato T. Laurencin (2022). Muscle degeneration in chronic massive rotator cuff tears of the shoulder: Addressing the real problem using a graphene matrix. Proc Natl Acad Sci U S A. 119(33), e2208106119. https://doi.org/10.1073/pnas.2208106119
  18. Takayoshi Otsuka, Ho-Man Kan, and Cato T. Laurencin (2022). Regenerative Engineering Approaches to Scar-Free Skin Regeneration. Regen. Eng. Transl. Med. 8(2), 225–247. https://doi.org/10.1007/s40883-021-00229-8